The Primary Cilium: A Vital Cellular Antenna for Human Health
The primary cilium is a small, hair-like structure found in most human cells. It acts as a crucial antenna, allowing cells to sense and respond to their external environment. This organelle plays a vital role in maintaining human health.
The primary cilium is involved in various physiological processes, from embryonic development to adult tissue maintenance. Its dysfunction has been linked to several human diseases, commonly called ‘‘Ciliopathies’’. These are rare diseases that typically affect multiple organs and tissues, often with a prominent neurological component.
The primary cilium coordinates the flow of information between the cell and its surroundings. It can detect and transmit various environmental cues, such as mechanical stimuli, chemical signals, and even light. This sensory function enables cells to adapt and respond appropriately to changes in their microenvironment. Moreover, the primary cilium actively participates in the regulation of cellular processes. By integrating and processing multiple signaling pathways, it plays a crucial role in coordinating cellular activities, including cell division, differentiation, and migration.
As our understanding of the primary cilium continues to evolve, we are uncovering its profound implications for human health. Unraveling the complex mechanisms underlying the primary cilium's functions holds the promise of developing novel therapeutic strategies for a wide range of diseases, ultimately improving the quality of life for affected individuals.
The mission of LOUKIL Lab @ Sanford Research is to develop cilia-based therapies by deepening our understanding of how cilia function in normal and pathological conditions, particularly those related to brain health. We are specifically interested in uncovering novel molecular mechanisms that govern cilia biogenesis and remodeling. Additionally, we aim to define the fundamentals of how the underexplored neuronal cilium modulates neuron morphology and connectivity. These processes can be disrupted in neurological disorders. Our ultimate goal is to uncover the true power of the cilium in the brain and fully leverage its therapeutic potential.
Cilia / Centrosome
Ongoing Projects